cbd edibles and Xyrem – Side Effects / Interactions

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cbd edibles and Xyrem explained. Xyrem is a rather versatile drug. In Italy and France, it’s also used as an anesthetic. In Italy, it also sometimes employed in helping alcoholism and alcohol withdrawal syndrome. Most of the time, though, it’s used to help treat narcolepsy; particularly the symptoms of daytime fatigue and sudden muscle weakness.

If you are on Xyrem, you might be wondering if cbd edibles can help your symptoms. Before combining cbd edibles with any medication, however, it’s important to find out if there will be any negative side effects or if it’s safe to take at all.

cbd edibles, Xyrem, and Suppression of the Central Nervous System

Xyrem pills

Xyrem, generically known as sodium oxybate, is a type of medication known as a central nervous system depressant.

The central nervous systemis an absolutely crucial system in the body. It includes the brain, cranial nerves, and spinal cord. This gives this system a massive amount of control. It controls your emotions, thoughts, desires, and movements. Even further, it plays a hand in involuntary functions such as your heart beating, breathing, body temperature, the release of hormones, and more.

Xyrem works as a CNS depressant because its goal is to help avoid daytime sleepiness by providing deep sleep at night. It also works to suppress the nervous system to avoid cataplexy. This is involuntary muscle movements resulting from a strong emotional response such as joy, anger, fear, or surprise.

cbd edibles also depresses the central nervous system. Because of this, it’s important to carefully adjust the dosages of both substances to avoid an overly depressed nervous system.

What Is the Danger of an Over-Suppressed Nervous System?

While controlled CNS depressionis very helpful – such as in the treatment of narcolepsy – it can quickly become a problem if it’s depressed too much.

Mild CNS depression can give someone the same feeling of taking a sedative. You might feel more tired, your speech pattern might become slow or slurred, or you might lose a little coordination. These aren’t severe reactions and they’re probably what you feel when you take a medication like Xyrem or a sleeping medication.

If CNS depression gets worse, there are other symptoms that you should keep an eye out for. These can include:

  • Poor or distorted judgment
  • Confusion
  • Further lethargy
  • Slowed heart rate
  • Slowed breathing

If CNS depression becomes particularly threatening, it can lead to delirium or even a coma. If more severe symptoms appear, it’s important to seek immediate medical attention.

This doesn’t necessarily mean that cbd edibles and Xyrem are fatally dangerous together but it does mean they can be a bad mix – especially if you are dosing them together on your own. Xyrem is a rather heavy-duty pharmaceutical If you want to combine these two substances, it’s imperative that you discuss the decision with your healthcare professional.

User Testimonials

A user on the narcolepsy thread on Redditposed the question if they should try cbd edibles oil with their Xyrem prescription. In response, they received an emphatic no from several other users.

The main message was that Xyrem is a serious pharmaceutical with impressive properties as a CNS depressant. They advised against not only the use of cbd edibles products but any substance with depressive properties such as alcohol or even other prescribed and over-the-counter medications.

At the bare minimum, they recommend talking to a healthcare professional such as a doctor or at the very least a pharmacist before taking anything with Xyrem.

Does cbd edibles Help Narcolepsy?

There has been researchon cbd edibles with different sleep disorders. One property that of cbd edibles that has been looked into is its use as a wake-inducing drug. This could be very helpful in treating conditions where individuals have trouble staying awake during the day due to conditions such as narcolepsy.

Research as to if these properties are enough to replace dedicated pharmaceuticals is limited and inconclusive as of right now.

What Are the Side Effects of Xyrem?

To understand why someone would seek an alternative to Xyrem, it’s important to consider what the side effects of Xyrem are. First and foremost, there is the fear of CNS depression, as we’ve already gone over. Additionally, users might experience;

  • Nausea and vomiting,
  • Nausea,
  • Shallow breathing, and;
  • Diarrhea

More severe side effects are possible as well. If you start struggling with bedwetting, sleepwalking, weakness, or hearing ringing in your ears, talk to your doctor. There is also a risk of changes in mindset and mood. This can include depression, thoughts of suicide, agitation, or even signs of psychosis or hallucinations.

Concerns of Misuse

Another concern of Xyrem is that it can easily become a drug someone is dependant on. Xyrem is a Schedule III controlled substance in the United States. The active ingredient in Xyrem – sodium oxybate – is a Schedule I drug which means it’s considered even more habit-forming.

This is a big reason that many are nervous about being prescribed this medication and might want an alternative. To reduce this risk, healthcare providers don’t prescribe Xyrem to just anyone and when they do prescribe it, they tend to check to make sure there isn’t a history of addiction in the patient or their family.


All in all, Xyrem probably isn’t the best drug to mix with cbd edibles. The results of both substances as depressants on the central nervous system can lead to dangerous levels of CNS depression. It’s better to follow the medication plan you have in place with Xyrem than to add in cbd edibles.

It should also be noted that Xyrem isn’t a prescription that doctors give out lightly. If you are prescribed Xyrem, your doctor is doing so in your best interest.

If you are still considering cbd edibles with Xyrem or cbd edibles instead of Xyrem, it’s critical not to make these decisions independently. Instead, take the time to discuss these decisions with your healthcare provider and listen to what they say. They are trained to understand drug interactions and are intimately familiar with your specific case. They are the ones that are qualified to make a professional decision on what substances are best for your body and its condition.

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